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Radium-223 treatment outcomes after multiple lines of mCRPC therapy in clinical practice: implication of pre-treatment spinal epidural disease

1 September 2017 | | URO - Urologic Oncology
There are a number of treatments now available to patients with metastatic castrate-resistant prostate cancer (mCRPC). However, the optimal timing and order in which they are given is less clear. Radium-223 was FDA-approved for mCRPC patients with symptomatic bone metastases...

Predicting bone scan positivity in non-metastatic CRPC

1 May 2016 | | URO - Urologic Oncology
There is evidence that suggests that early treatment with chemotherapy, immunotherapy or hormone therapy leads to a better response in patients with asymptomatic metastatic castrate resistant prostate cancer (CRPC). This study aimed to predict bone scan positivity in patients with...

The potential of statin use in castrate resistant prostate cancer treatment

1 May 2016 | | URO - Urologic Oncology
One of the mechanisms by which prostate cancer achieves castrate resistance is through de novo intratumoral production of androgens. Reactivation of androgen receptors results in promotion of cell survival and proliferation pathways despite castrate serum testosterone levels. As androgen synthesis...

Giggle incontinence – not a laughing matter!

4 May 2023 | | URO - Functional / Reconstructive Urology
For many decades, the condition of giggle incontinence (enuresis risoria, giggle micturition) has remained a rare and poorly understood condition. Patients (90% female) present in their teens, with the history revealing an issue for many years. It is debilitating and...

Trials offering cytoreductive surgery for men with de novo synchronous metastatic prostate cancer

8 November 2021 | | URO - Basic Science Research, URO - Urologic Oncology
Life expectancy in men diagnosed with de novo synchronous metastatic hormone-sensitive prostate cancer (mHSPC) has risen to a median of 4.8 years with upfront systemic agents (such as docetaxel) in addition to standard androgen deprivation therapy (ADT) [1-3]. Within this...

International urology returns to Scotland

31 March 2025 | URO - Core Urology
Founded in 1907, the SIU has established itself as the premier international professional society for urologists. As global interdependence increases, so does the relevance of the Society’s mission to enable urologists in all nations to apply the highest standards of...

Urodynamics in review: stress urinary incontinence in women produced by the Urodynamics Committee of the ICS

1 November 2018 | | URO - Functional / Reconstructive Urology, URO - Infection, URO - Neurourology
Urodynamic studies (UDS) are the best tools to objectively assess the lower urinary tract dysfunction (LUTD) of various aetiologies [1]. According to the general understanding and consensus of the medical community UDS should be performed only when they will change...

How to set up and run a cadaveric dissection course

1 January 2018 | | URO - Core Urology
Conducting and implementing a cadaveric dissection course requires careful planning. Rachel Edmiston, Rajesh Anmolsingh, Omar Mirza and Nirmal Kumar offer a guide to individuals highlighting the licensing and legal processes involved with the use, preservation and disposal of cadavers in...

So you want to go on a Fellowship: part 1

1 January 2016 | | URO - Core Urology
Look out for part 2 of this series later in 2016 when the author will discuss settling into the research role of his fellowship and will reflect on his first year overseas. This is the first in a series of...

The role of transperineal template biopsies in the diagnosis of prostate cancer

1 March 2014 | | URO - Urologic Oncology
The case In 2002, Mr A, a 64-year-old software engineer, was referred by his GP for further investigation of a raised prostate specific antigen (PSA) of 6.2. His prostate felt benign. He underwent transrectal ultrasound guided (TRUS) prostate biopsies. This...

Management of RHC in prostate cancer with selective embolisation and hyperbaric oxygen therapy

4 July 2024 | | URO - Urologic Oncology
Prostate cancer is one of the most prevalent malignancies affecting men worldwide. Radiotherapy is a common treatment modality for localised and locally advanced prostate cancer. While radiotherapy can be effective, it may lead to complications such as radiation-induced haemorrhagic cystitis...

Cutting on the Staff

1 March 2014 | | URO - Technology, URO - Endourology & Stones
In this series of articles I am going to show you some of the exhibits contained in the BAUS Virtual Museum of the History of Urology which is part of the BAUS website (www.baus.org.uk). In the last article I described...