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Surgery in disorders of sexual development with gender issues

1 March 2017 | | Andrology, Paediatric Urology | 17β hydroxy steroid dehydrogenase, 17βHSD, 5α reductase deficiency, AIS, Androgen insensitivity syndrome, CAH, Chromosomal anomalies, Congenital adrenal hyperplasia, DSD, Disorders of sex development, Genital surgery in children, Gonadal dysgenesis, Gonadal dysplasia, Hypospadias, Micropenis, Mixed gonadal dysgenesis, Ovo-testicular DSD
After the initial consensus meeting of 10 years ago on disorders of sex development (DSD) with the introduction of the new terminology and classification there are still abundant controversial issues associated with the management of children with these conditions. This...

BCG strain differences have an impact on clinical outcome in bladder cancer immunotherapy

1 March 2015 | | Urologic Oncology | Animal, BCG Connaught, BCG Tice, BCG vaccine, Flow cytometry, Immunotherapy, Intravesical drug administration, Models, Randomized controlled trial, Urinary bladder neoplasms
Bacillus Calmette-Guérin (BCG) has been part of the treatment algorithm for non-muscle invasive bladder cancer (NMIBC) for a number of years. In this single centre, prospective, randomised trial, two of the most commonly available strains, BCG Connaught and BCG Tice,...

Adjuvant radiotherapy versus wait-and-see after radical prostatectomy

1 September 2014 | | Urologic Oncology | Adjuvant radiotherapy, Prostate cancer, Prostate-specific antigen, Radical prostatectomy, Wait-and-see
Optimum treatment modalities in prostate cancer continue to evolve, with debates at each stage of the evolution process, from focal therapy to radical treatment. In this randomised study, Wiegel et al. investigated the role of adjuvant radiotherapy following open radical...

The EP2 receptor – a novel target for prostate cancer?

1 July 2014 | | Basic Science Research, Urologic Oncology
This basic science paper sets out to evaluate the effects that celecoxib, a selective cyclo-oxygenase-2 (COX-2) inhibitor, have on prostate cancer cell lines and evaluated the mechanisms behind these effects. COX-2 induces the production of prostaglandins, which promote cell proliferation...

Read all about it May/Jun 2019

1 May 2019 | Technological Developments, Urologic Oncology
It can be awkward when a patient asks you about a report in their favourite tabloid detailing an amazing research breakthrough or a ‘cutting-edge’ new treatment / test and you don’t know what they are talking about! So this section...

What is new in lasers for endourology: looking into the future

7 January 2021 | | Endourology and Stones, Technological Developments
From the first cystoscopic argon and neodymium-YAG (yttrium-aluminium-garnet) laser used for bladder tumours in 1976 by Staehler et al. [1], lasers have proven to be a versatile and an evolving tool in the therapeutic management of a variety of urological...

Understanding Stauffer’s syndrome

1 May 2018 | | Andrology, Basic Science Research, Endourology and Stones, Functional Urology, Infection, Neurourology, Paediatric Urology, Technological Developments, Trauma and Emergency Urology, Urologic Oncology, Uroradiology
Who was Stauffer and what is Stauffer’s syndrome? Maurice Stauffer (1915-1994) was a gastroenterologist at the Mayo Clinic in Rochester, United States, and in 1961 first characterised the non-metastatic, paraneoplastic effects of renal cell carcinoma (RCC) on liver size and...

History of prostate biopsy – part 1

1 January 2018 | | Basic Science Research, Technological Developments, Urologic Oncology
Part 2 of this topic is available here. Prostate biopsy (PBx) to exclude cancer has been part of clinical practice since the beginning of the 20th Century. PBx techniques have evolved over time to optimally address some of the unique...

The PROMIS trial – time for multi-parametric MRI before a first prostate biopsy

1 March 2017 | | Urologic Oncology, Uroradiology
Whilst the relatively random process of 12 core transrectal ultrasound guided (TRUS) prostate biopsy remains by far the most widely employed approach to prostate cancer diagnosis in the UK, its flaws as a standalone diagnostic strategy are increasingly apparent. TRUS-biopsy...

Read all about it Jul/Aug 2017

1 July 2017 | Andrology, Basic Science Research, Endourology and Stones, Functional Urology, Infection, Neurourology, Paediatric Urology, Reconstructive Urology, Technological Developments, Trauma and Emergency Urology, Uroradiology, Urologic Oncology
It can be awkward when a patient asks you about a report in their favourite tabloid detailing an amazing research breakthrough or a ‘cutting-edge’ new treatment / test and you don’t know what they are talking about! So this section...

Read all about it May/Jun 2018

1 May 2018 | Andrology, Basic Science Research, Endourology and Stones, Functional Urology, Infection, Neurourology, Paediatric Urology, Reconstructive Urology, Technological Developments, Trauma and Emergency Urology, Urologic Oncology, Uroradiology
It can be awkward when a patient asks you about a report in their favourite tabloid detailing an amazing research breakthrough or a ‘cutting-edge’ new treatment / test and you don’t know what they are talking about! So this section...

Read all about it Mar/Apr 2015

1 March 2015 | Andrology, Basic Science Research, Endourology and Stones, Functional Urology, Infection, Neurourology, Paediatric Urology, Reconstructive Urology, Technological Developments, Trauma and Emergency Urology, Urologic Oncology, Uroradiology
It can be awkward when a patient asks you about a report in their favourite tabloid detailing an amazing research breakthrough or a ‘cutting-edge’ new treatment / test and you don’t know what they are talking about! So this section...