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Abiraterone acetate in men with castration-resistant prostate cancer
With emerging results from the Stampede and Latitude studies, abiraterone has taken the forefront in the management of metastatic prostate cancer while researchers try to identify the ideal timing for administration. It is a potent inhibitor of CYP17 which results...
The role of acupuncture in managing overactive bladder
Overactive bladder (OAB) affects 17% of American men and women and represents a burden in terms of both quality of life and finances. Alternative therapies may be sought for this condition as there is a high drop-out rate with regards...
PET imaging of prostate-specific membrane antigen in prostate cancer
Molecular imaging utilising prostate-specific membrane antigen (PSMA) as a target has increasingly been mentioned at key conferences and meetings. PSMA is a membrane metalloenzyme that is overexpressed in prostate cancer, with the degree of expression appears to correlate with tumour...
Effect of collimation on radiation dose during ureteroscopy
Over 60,000 ureteroscopies are performed annually in the UK. During these procedures radiation is used and there are concerns regarding the cumulative dose during a surgeon’s career. Common ways to minimise the dose to the theatre team are wearing lead...
How effective are intravesical therapies for bladder pain syndrome?
The objective of this study was to review the clinical efficacy of currently available products for the intravesical treatment of bladder pain syndrome (BPS) / interstitial cystitis (IC) and to assess their pharmaco-economic impact. Nineteen articles were reviewed, including five...
Cord compression in cancer
This article will be of great interest to uro-oncologists. Vertebral metastasis occurs in 3-5% of all cancers (most commonly in prostate, breast and lung cancer). It can cause pain, vertebral collapse and cord compression. Data from the National Institute for...
Intermittent self-catheterisation
Intermittent self-catheterisation (ISC) is used in everyday practice for bladder dysfunction. This study from Southampton, UK presents a Cochrane review of different catheter designs, user satisfaction and incidence of urinary tract infection (UTI), etc. The following factors were looked at:...
Cystolithotripsy using the holmium laser: evolving uses for the laser lithotrite
This small prospective study examined 20 patients who were undergoing laser cystolithotripsy for bladder stones. Laser lithotripsy was performed using either a 365 or 550µm holmium:YAG laser fibre with a power setting of 1.0J and a frequency of 10Hz. Stone...
MRU for diagnosis of paediatric ureteral stricture
Hydronephrosis is diagnosed antenatally in approximately 1-5% of all pregnancies. A rare cause is ureteral stricture, found in 4% of these cases. This study reports a series of 28 strictures diagnosed over a 10-year period by magnetic resonance urography (MRU)...
Patient-reported outcomes after prostate cancer treatment
This study used the survivorship (LIVESTRONG) care plan tool to identify patient-reported toxicities that occurred following treatment for prostate cancer. All patients had undergone treatments, which were considered to have similar oncological endpoints. The tool asked patients questions with regard...
The survival impact of neoadjuvant hormonal therapy before radical prostatectomy
There is increasing evidence for the role of radical prostatectomy in select patients with T3-T4 prostate cancer (as part of multimodal therapy). This retrospective multicentre study explored the benefit of neoadjuvant hormonal therapy before radical prostatectomy specifically in patients with...
