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The EP2 receptor – a novel target for prostate cancer?

This basic science paper sets out to evaluate the effects that celecoxib, a selective cyclo-oxygenase-2 (COX-2) inhibitor, have on prostate cancer cell lines and evaluated the mechanisms behind these effects. COX-2 induces the production of prostaglandins, which promote cell proliferation...

Can PET/CT help in selecting treatment for patients with muscle-invasive bladder cancer more appropriately?

Radical cystectomy is one of the most drastic procedures that urological patients have to undergo with a five-year mortality of around 50% in those with organ-confined disease at presentation. Traditional imaging is with contrast-enhanced computed tomography (CT) but lymphadenectomy often...

A phase II dose-ranging study of mirabegron in patients with OAB

This was a multinational, multicentre, randomised, double–blind, double-dummy, parallel group placebo- and active- controlled phase II study. The study enrolled 1108 men and women aged 18 and over. The criteria were: patients must have had overactive blader (OAB) symptoms for...

Trade-offs between risks and benefits of localised prostate cancer treatments – the COMPARE study

We know little about the trade-offs men make when considering the oncological and functional outcomes of individual treatment options for localised prostate cancer, and decisions are often influenced by physician opinion. The likely compromised functional results are viewed as a...

iMEDicare – Pelvic Health Naturally are on a mission

Since 2022, the team at iMEDicare has been scaling the highest peaks of various European nations to raise funds for a selection of their favourite charities. Their mountain adventures have so far taken them to the top of Scotland, Wales,...

RSM (Royal Society of Medicine) Endourology Day

Now a staple in the national endourology calendar, this meeting will highlight cutting-edge developments in stone disease, upper tract TCC, and BPH. The day concludes with the much-anticipated, informal 'Challenging Cases' session, a lively forum for discussion and learning.

Effects of orchidopexy upon testicular temperature

The undescended testis (cryptorchidism) is the most common correctable disorder in paediatric urology (1-4.6% of newborns). An important role of the scrotum is to keep the temperature of the testes 2-40C below core body temperature. Here, Shiraishi et al. from...

Children’s bowel and bladder health takes centre stage in World Continence Week

World Continence Week (16–22 June in 2025) is an annual global awareness campaign that shines a spotlight on bowel and bladder issues. This year, the focus was on children, as ERIC, The Children’s Bowel and Bladder Charity brought the issue...

Convatec Healthcare is changing

Forever Caring At Convatec, ‘forever caring’ is our promise to give patients and healthcare providers the support they need as we bring to life our vision of pioneering trusted medical solutions to improve the lives we touch. Existing complications of...

Prostate Cancer UK announced as official charity partner for MOBO Awards

The stage is set! Global dancehall queen Spice, UK rap kings Krept and Konan and the multi-talented Bashy are the first wave of performers announced to ignite the stage at the 2025 MOBO Awards.

What is new in lasers for endourology: looking into the future

From the first cystoscopic argon and neodymium-YAG (yttrium-aluminium-garnet) laser used for bladder tumours in 1976 by Staehler et al. [1], lasers have proven to be a versatile and an evolving tool in the therapeutic management of a variety of urological...

Intravesical GAG replacement therapies for bladder pain syndrome / interstitial cystitis – an update

The barrier function of the glycosaminoglycan (GAG) layer of the urothelium was identified by Parsons in 1975, and intravesical therapies to treat chronic inflammatory conditions of the bladder were developed soon after. However, the active role of the urothelium in...