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The EP2 receptor – a novel target for prostate cancer?
This basic science paper sets out to evaluate the effects that celecoxib, a selective cyclo-oxygenase-2 (COX-2) inhibitor, have on prostate cancer cell lines and evaluated the mechanisms behind these effects. COX-2 induces the production of prostaglandins, which promote cell proliferation...
Can PET/CT help in selecting treatment for patients with muscle-invasive bladder cancer more appropriately?
Radical cystectomy is one of the most drastic procedures that urological patients have to undergo with a five-year mortality of around 50% in those with organ-confined disease at presentation. Traditional imaging is with contrast-enhanced computed tomography (CT) but lymphadenectomy often...
A phase II dose-ranging study of mirabegron in patients with OAB
This was a multinational, multicentre, randomised, double–blind, double-dummy, parallel group placebo- and active- controlled phase II study. The study enrolled 1108 men and women aged 18 and over. The criteria were: patients must have had overactive blader (OAB) symptoms for...
Trade-offs between risks and benefits of localised prostate cancer treatments – the COMPARE study
We know little about the trade-offs men make when considering the oncological and functional outcomes of individual treatment options for localised prostate cancer, and decisions are often influenced by physician opinion. The likely compromised functional results are viewed as a...iMEDicare – Pelvic Health Naturally are on a mission
Since 2022, the team at iMEDicare has been scaling the highest peaks of various European nations to raise funds for a selection of their favourite charities. Their mountain adventures have so far taken them to the top of Scotland, Wales,...Children’s bowel and bladder health takes centre stage in World Continence Week
World Continence Week (16–22 June in 2025) is an annual global awareness campaign that shines a spotlight on bowel and bladder issues. This year, the focus was on children, as ERIC, The Children’s Bowel and Bladder Charity brought the issue...Indeterminate renal lesions – a pragmatic imaging approach
The incidence of renal cell carcinoma (RCC) in the UK has increased steadily over the last two decades, largely driven by the increasing use of abdominal imaging and the incidental detection of small renal lesions [1]. The majority of incidental...Training to be a urologist: how risky is it?
The NHS and urology face challenging times in trying to provide quality patient care efficiently and economically. Urology trainees are experiencing conflicting pressures with a new contract, a challenging on-call system and changing training requirements in an overstretched, centralised service...Sepsis syndrome in urology
There are approximately 100,000 cases of sepsis per year in the UK, of which 37,000 result in death (this is more than prostate cancer, breast cancer, HIV / AIDS and road traffic accidents combined). Urosepsis is defined as sepsis caused...Sustainable healthcare: what steps can urologists take?
Human health is intrinsically linked to environmental health, making the ever-pressing climate crisis fundamentally a public health emergency. The healthcare sector is responsible for 8% of the UK’s greenhouse gas (GHG) emissions worldwide [1]. As the largest publicly funded healthcare...Prostate Cancer UK announced as official charity partner for MOBO Awards
The stage is set! Global dancehall queen Spice, UK rap kings Krept and Konan and the multi-talented Bashy are the first wave of performers announced to ignite the stage at the 2025 MOBO Awards.
