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Solifenacin for children and adolescents with overactive bladders
Solifenacin (VESIcare®) is the second-line anti-muscarinic medication of choice for my patients with overactive bladder (oxybutynin being my initial choice). However, currently, it remains unlicensed for use in children. Newgreen et al. have evaluated the long-term safety and efficacy of...The emerging role of physician associates in urology
The physician associate (PA) is a new role in the NHS which has expanded across medical and surgical specialties to include urology. In the USA, it has long been an established field of practice where physician assistants work autonomously within...What did the Romans ever do for us?
In this series of articles I am going to show you some of the exhibits contained in the Museum of Urology, hosted on the BAUS website (www.baus.org.uk). Previously in this column, I told you about the Saxons and how they...
Activity of enzalutamide in men with mCRPC is affected by prior treatment with abiraterone and / or docetaxel
This study reported on the real-world clinical outcomes of patients at seven academic institutions who were treated with enzalutamide, with the primary objective being to assess the effect of prior therapies (namely abireterone and docetaxel). Three hundred and ten patients...
Performance status may alter outcomes in those treated with abiraterone
The drug therapies available for those with metastatic castrate-resistant prostate cancer have increased over the past few years. Abiraterone, a CYP17 inhibitor, has been proven effective in phase three trials, however those with poor performance status were largely under-represented in...TUF Warriors – joining the fundraising fight
What is the TUF Warrior programme? The Urology Foundation (TUF) Warrior programme is designed to support core trainees, clinical fellows and foundation doctors interested in urology. It creates opportunities to develop extracurricular interests, connect with patients, boost applications for specialty...
Retention after Botox therapy in OAB
Treatment of overactive bladder (OAB) has a wide spectrum. The first step is lifestyle modifications, the second step is pharmacotherapy and the third line is intradetrusor injections with Botox®. This retrospective study is from Tennessee, USA in non-neurogenic and refractory...
Oestrogens and OAB
This is a multicentre study from Europe. The female genitals and lower urinary tract have a common embryological origin arising from urogenital sinus. Therefore, both could be sensitive to female sex steroid hormones. Oestrogens and progesterone receptors have been demonstrated...
New therapy for overactive bladder
Overactive bladder (OAB) is a complex symptom that can adversely affect quality of life. So far pharmacotherapy has focused on anti-cholinergic drugs. Recently, beta-adrenoreceptors have been identified as having an effect on the detrusor muscle and urothelium. Beta-3 is the...
PTNS in overactive bladder
This article will be of interest to those who undertake percutaneous tibial nerve stimulation (PTNS) or are planning to start doing so. This is a computer aided search between 2000-2011 to identify randomised controlled trials (RCT), controlled clinical trials (CCT)...Uroscopy
In this series of articles I am going to show you some of the exhibits contained in the Museum of Urology, hosted on the BAUS website (www.baus.org.uk). You may feel somewhat distanced from the medical practitioners of mediaeval Florence but...
