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MSKCC prostate cancer screening guidelines – is it the way forward?

The Memorial Sloan Kettering Cancer Center (MSKCC) developed prostate cancer screening recommendations first in 2011 as a response to three limitations of previous screening guidelines: insufficient evidence base, failure to link screening with treatment, and lack of risk stratification. To...

Increasing PSA after negative prostate biopsy - solving the clinical puzzle

There are standard guidelines for first transrectal ultrasonography (TRUS) guided biopsy in a patient presenting with elevated prostate-specific antigen (PSA) or suspicious digital rectal examination (DRE) findings. Patients are generally warned before a TRUS biopsy in respect of a false...

Can antibiotics reduce ‘unnecessary’ prostate biopsies?

With numerous factors capable of influencing prostate specific antigen (PSA) levels and therefore the likelihood of biopsy, this multi-centred randomised controlled trial (RCT) was designed to see if two weeks of ciprofloxacin compared to placebo would significantly reduce PSA levels...

No Margin for Error: A Surgeon’s Struggle Repairing Hypospadias

No Margin for Error is not only a memoir of the ‘pound for pound’ most influential hypospadiologist of the 21st century, but also a blueprint to self-examination and improvement. It’s an essential read for any urologist starting their career to...

Scientific Advances in Reconstructive Urology and Tissue Engineering

Scientific Advances in Reconstructive Urology and Tissue Engineering stands as a beacon in the field, providing a comprehensive exploration of cutting-edge developments in the intersection of reconstructive urology and tissue engineering. Edited by Matthias D Hofer, this paperback edition comprises...

Pre-transplant management of valve bladder

This paper examines the evidence concerning the timing, indications and problems associated with augmentation cystoplasty (AC), posterior urethral valves (PUV), and end stage renal failure (ESRF) using a literature review via Medline, Cochrane library and LILACS databases. Two search strategies...

Is surgical antibiotic prophylaxis necessary for paediatric orchiopexy?

With the rise of resistant organisms to most commonly used antibiotics, there is a plea for judicious use of antibiotics, especially for clean surgical procedures. Potential adverse events associated with antibiotic use include allergic reaction (including anaphylaxis), clostridium difficile infection,...

Comparison of the microbiological milieu of CIC patients

Children performing clean intermittent catheterisation (CIC) have a higher risk of bacteriuria. This occasionally can lead to full urinary tract infection (UTI) which can influence long-term renal function. Hydrophilic catheters are said to be less traumatic to the urothelium and...

Do adult men with untreated ventral penile curvature have adverse outcomes?

The history of ventral penile curvature if untreated in childhood is not known. The authors tried to assess this by performing an online survey of adults who had untreated ventral penile curvature using a Facebook advertised survey. Their outcome measures...

Tackling stones in children: is it difficult to crack on?

The incidence of stone disease in the paediatric population has been increasing worldwide, particularly for the adolescent age group (12–17 years of age). In this article the authors discussed the evolutions of percutaneous nephrolithotomy (PCNL) and ureteroscopy (URS) in children....

IC and risk of CHD

Bladder pain syndrome / interstitial cystitis (BPS/IC) is a chronic, multifactorial and relapsing condition. Aetiology includes: inflammation, allergic, neuropathic, auto immune, vascular factors, etc. This study from Taiwan aimed to investigate the risk of coronary heart disease (CHD) among IC...

Reflux oesophagitis and risk of interstitial cystitis: is there a link?

This study aims to explore the potential link between reflux oesophagitis (RE) and interstitial cystitis / bladder pain syndrome (IC/BPS). IC/BPS is a chronic disease which is difficult to diagnose and treat. Two percent of the population may be affected....