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IC and risk of CHD
Bladder pain syndrome / interstitial cystitis (BPS/IC) is a chronic, multifactorial and relapsing condition. Aetiology includes: inflammation, allergic, neuropathic, auto immune, vascular factors, etc. This study from Taiwan aimed to investigate the risk of coronary heart disease (CHD) among IC...
Adolescents and adults in paediatric urology clinics
This elegant descriptive paper retrospectively reviewed cases seen in a paediatric urology clinic with respect to age, diagnosis and presentations in a major Brazilian city. Of 521 patients, 404 were <12 years old, 103 were between 12-18 and 14 were...
Oestrogens and OAB
This is a multicentre study from Europe. The female genitals and lower urinary tract have a common embryological origin arising from urogenital sinus. Therefore, both could be sensitive to female sex steroid hormones. Oestrogens and progesterone receptors have been demonstrated...
Surgical management of DSD
The management of children with disorders of sex development (DSD) continues to be controversial. This editorial was written in response to a review article in the same edition on ‘Evidence regarding cosmetic and medically unnecessary surgery in infants’ by M...
Secondary bladder cancer following upper tract urothelial cancer
Upper tract urothelial carcinoma (UTUC) comprises <5% of all urothelial cancers. A certain proportion of patients with UTUC will develop secondary bladder urothelial cancer (BUC). This paper has retrospectively examined records obtained from several cancer USA population-based registries of more...
Ureteric injury rates during robot assisted radical prostatectomy
Jhaveri et al. and colleagues have produced a timely report on the incidence of ureteric injuries during robot assisted radical prostatectomy. They reviewed the complications of 6442 consecutive patients treated with robot assisted prostatectomy at the same institution by one...
The risk of failure after primary orchidopexy
Surgical standards for revalidation are growing in the UK. For paediatric surgery, primary orchidopexy is thought to be one procedure that could be used as a ‘plumb line’ for this. These authors looked at 1538 boys who underwent 1886 orchidopexies...
Intermittent vs. continuous hormonal therapy for metastatic prostate cancer
Continuous androgen deprivation therapy (cADT) is the standard management for metastatic prostate cancer (mPCa). Intermittent androgen deprivation therapy (iADT) is sought to have better quality of life (QoL) and adverse events profile during off-treatment period. This multicentre European randomised study...
Antibiotics and flexible cystoscopy
This study is from Memorial Sloan-Kettering Hospital in New York, USA. Thousands of flexible cystoscopies are performed every day worldwide. Do they need antibiotic cover? Flexible cystoscopy may cause urinary tract infection (UTI) in less than 10% of cases. Asymptomatic...
New therapy for overactive bladder
Overactive bladder (OAB) is a complex symptom that can adversely affect quality of life. So far pharmacotherapy has focused on anti-cholinergic drugs. Recently, beta-adrenoreceptors have been identified as having an effect on the detrusor muscle and urothelium. Beta-3 is the...
Is surgical antibiotic prophylaxis necessary for paediatric orchiopexy?
With the rise of resistant organisms to most commonly used antibiotics, there is a plea for judicious use of antibiotics, especially for clean surgical procedures. Potential adverse events associated with antibiotic use include allergic reaction (including anaphylaxis), clostridium difficile infection,...
