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Recent advances in the management of castration resistant prostate cancer

1 November 2017 | | Urologic Oncology
Castrate resistant prostate cancer (CRPC) is defined by disease progression despite androgen-deprivation therapy lowering testosterone to castrate levels. It may present as a rise in serum levels of prostate specific antigen (PSA), progression of pre-existing disease, or the appearance of...

Post-prostatectomy incontinence

4 May 2020 | | Functional Urology, Urologic Oncology
Urinary incontinence following prostate surgery (post-prostatectomy incontinence or PPI) is a significant complication that can have a profoundly negative impact on the quality of life of patients suffering with it. It may become a barrier to physical activity and social...

Catheters and incontinence after radical prostatectomy: Preparing (but not scaring) men

1 May 2018 | | Infection, Functional Urology, Urologic Oncology
Every year about 6000 men in the UK undergo radical prostatectomy (RP) for treatment of prostate cancer [1]. Despite surgical advances, RP continues to be associated with significant side-effects including urinary incontinence (UI) [2]. Immediately following removal of the urinary...

Biomarkers in prostate cancer detection

1 July 2018 | | Basic Science Research, Technological Developments, Urologic Oncology
Prostate cancer (PCa) is the second most common cancer in men with an estimated prevalence of 1.1 million worldwide in 2012. This heterogeneous disease resulted in approximately 307,000 deaths, making it the fifth leading cause of cancer-related death in men...

Preventive pharmacological therapy for kidney stones

1 May 2016 | | Endourology and Stones | drug therapy, kidney calculi, medication adherence, patient compliance, prevention and control
Kidney stones are common, painful and are a chronic disease with a high lifetime risk of recurrence. Without treatment 35-50% of patients experience a second stone within five years of their first experience. Thiazide diuretics, alkali citrate treatment and allopurinol...

Solifenacin and mirabegron are safe and effective in combination

1 September 2015 | | Functional Urology | Combination therapy, Mirabegron, Overactive bladder, Solifenacin
Antimuscarinic agents remain the mainstay of medical management of bladder overactivity. Limited somewhat by their tolerability, the new agent mirabegron, a β3-adrenoreceptor agonist, has been approved as an alternative. There is little known however about the possible synergistic effects of...

MRI targeted transperineal prostate biopsy: a local anaesthetic approach

1 March 2018 | | Urologic Oncology
Transperineal template biopsy remains the gold standard investigation in diagnosis of prostate cancer. Data from the PROMIS study demonstrated the low sensitivity of transrectal ultrasound (TRUS) biopsy as a diagnostic tool, and highlighted the need for a better diagnostic pathway....

Use of Clavien-Dindo classification in urology part 1 – pelvic surgery

1 March 2016 | | Urologic Oncology
There is no widely accepted system to classify postoperative complications. It is necessary to compare the outcome and complications while validating a new surgical procedure or one of the surgical approaches of a particular condition. Several parameters have long been...

Urethroplasty: a review of indications, techniques and outcomes

1 March 2018 | | Reconstructive Urology
Urethral stricture is the most common cause of lower urinary tract obstruction in men aged between 20 and 40, carrying an estimated overall prevalence of 0.5% in the UK [1] and results in around 17,000 hospital admissions annually [2]. Endoscopic...

What’s new in post prostatectomy incontinence?

1 January 2017 | | Functional Urology
With an ageing population, the number of men being diagnosed with prostate cancer each year is steadily rising. With more specific investigations, such as multiparametric magnetic resonance imaging (MpMRI) and transperineal biopsies, the number of cases diagnosed at an earlier...

Read all about it Jan/Feb 2021

19 February 2021 |
Read all about it... It can be awkward when a patient asks you about a report in their favourite tabloid detailing an amazing research breakthrough or a ‘cutting-edge’ new treatment / test and you don’t know what they are talking...

Urological Complications of Malignancy

1 January 2014 | | Urologic Oncology
Case 1 1. What does this sagittal magnetic resonance imaging (MRI) scan show? 2. Which cancers commonly cause this? 3. What is the acute management? Case 2 1. What is the diagnosis? 2. What local effects can this mass cause?...