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The potential of statin use in castrate resistant prostate cancer treatment
One of the mechanisms by which prostate cancer achieves castrate resistance is through de novo intratumoral production of androgens. Reactivation of androgen receptors results in promotion of cell survival and proliferation pathways despite castrate serum testosterone levels. As androgen synthesis...
LUTS among Caucasian-European men who have sex with men: findings from a real-life survey
This study is the first of its kind to report an association between men who have sex with men (MSM) and lower urinary tract symptoms (LUTS). Nine hundred and forty-nine consecutive individuals who presented to a uro-andrology clinic for complaints...Read all about it Mar/Apr 2017
It can be awkward when a patient asks you about a report in their favourite tabloid detailing an amazing research breakthrough or a ‘cutting-edge’ new treatment / test and you don’t know what they are talking about! So this section...Erectile dysfunction part II: treatment
Introduction The identification of specific risk factors associated with erectile dysfunction (ED) allows patients with mild or moderate ED to undergo a series of lifestyle changes, which may provide enough improvement in the erectile function to avoid pharmacotherapies. Cessation of...From overseas to the UK: initial impressions
A few years ago we published stories from three international medical graduates detailing their experience of working as registrars in the UK (https://www.urologynews.uk.com/education/trainees-forum/post/initial-impressions-of-urology-in-the-uk-from-overseas-trainees). Here are three new countries and three new opinions. Dinelle Sirjuesingh, Trinidad and Tobago Trinidad and Tobago...What to expect when meeting a statistician
There are a growing number of statisticians working closely with medics from all specialties. They have different training but they are driven by the same goal: to perform high quality evidence-based clinical research [1,2]. In a perfect world we would...Urology around the world: India: past, present, and future
Past India has the largest population in the world, standing at 1.43 billion as of September 2023. This vast population across a huge geographical area brings unique healthcare challenges, including the full range of urologic conditions. Urology is a relatively...Demanding cases or nightmares in uro-oncology? Jan/Feb 2023
Radical surgical treatment of prostate cancer has become minimally invasive owing to robotic assisted laparoscopic technology [1]. Patients who undergo robotic assisted radical prostatectomy (RARP) often have lower risk of morbidity compared to an open approach. However, patients with a...
HOLEP and detrusor underactivity
Lower urinary tract symptoms (LUTS) are common among adult males, significantly influence quality of life (QoL) and contribute to pressure on the NHS. LUTS are conventionally associated with benign prostatic obstruction (BPO), which is commonly observed during the histological progression...
Prostatic calculi and CIC
Although the clinical importance of prostate calculi has been debatable, it is a disease that can cause a plethora of symptoms and signs – sometimes in disguise. Clean intermittent catheter (CIC) is the gold standard method for bladder rehabilitation /...
Ulcerative colitis has a positive association with prostate cancer risk
This large-scale meta-analysis, incorporating studies from several population-based studies, evaluated the association between inflammatory bowel disease (IBC) and prostate cancer (Pca). Emerging evidence has suggested that IBD is a risk factor for extra-intestinal malignancies which may be due to an...
